Sitamaquine tosylate - CAS 1019640-33-5

Sitamaquine is an antileishmanial agent.1It is active againstL. donovani, L. infantum, L. mexicana, L. braziliensis, andL. tropica (EC50s = 9.5-19.8 μM) . It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH), in a cell-free assay when used at concentrations ranging from 10 to 200 μM.2Sitamaquine (100 μM) increases intracellular levels of reactive oxygen species (ROS) and decreases intracellular ATP levels, as well as induces phosphatidylserine externalization, chromatin fragmentation, and depolarization of the mitochondrial membrane potential, markers of apoptosis, inL. donovanipromastigotes.

Parasite, Others, Mitochondrial Metabolism

Others, Metabolism, Microbiology/Virology

1019602

C28H41N3O4S

515.71

Cc1ccc(cc1)S(O)(=O)=O.CCN(CC)CCCCCCNc1cc(OC)cc2c(C)ccnc12

-20°C

Ice Packs

Small Compound