Sitravatinib malate - CAS 2244864-88-6

Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively.), shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.

VEGFR, FLT, Discoidin Domain Receptor (DDR), c-Kit, Trk receptor, TAM Receptor

Angiogenesis, Tyrosine Kinase/Adaptors

2244770

C37H35F2N5O9S

763.76

[C@H](CC(O)=O)(C(O)=O)O.C(NC1=CC(F)=C(OC2=C3C(C=C(S3)C4=CC=C(CNCCOC)C=N4)=NC=C2)C=C1)(=O)C5(C(NC6=CC=C(F)C=C6)=O)CC5

-20°C

Ice Packs

Small Compound