SJ-C1044 - CAS 2121503-76-0

SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.

MEK, ERK, Tie-2, Raf, c-Fms, Ras, VEGFR

MAPK, GPCR/G Protein, Angiogenesis, Tyrosine Kinase/Adaptors

2121427

C25H14F7N7O

561.41

O=C(NC1=CC(=CC=C1F)NC2=NC=CC=C2C=3N=CN=C4N=CNC43)C=5C=C(C=C(C5)C(F)(F)F)C(F)(F)F

-20°C

Ice Packs

Small Compound