SJ1008030 - CAS 2863634-96-0

SJ1008030 (compound 8), a JAK2 PROTAC, selectively degrades JAK2. It demonstrates potent activity against MHH–CALL-4 cells, with an EC50 of 5.4 nM and an IC50 of 32.09 nM. This compound holds potential for leukemia research [1].

Others, JAK, PROTACs

Tyrosine Kinase/Adaptors, Angiogenesis, PROTAC, JAK/STAT signaling, Stem Cells, Others, Chromatin/Epigenetic

2863538

C42H43N13O7S

873.94

CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1nc(Nc2ccc(cc2)C(=O)NCCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)nc2[nH]ccc12

-20°C

Ice Packs

PROTAC