SJ10542 - CAS 2789678-92-6

SJ10542, a phenyl glutarimide (PG) -PROTAC, demonstrates potent and selective activity against JAK2/3 by exhibiting DC50 values of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. It employs a PG ligand for cereblon (CRBN) recruitment [1].

JAK, PROTACs

Tyrosine Kinase/Adaptors, PROTAC, JAK/STAT signaling, Stem Cells, Angiogenesis, Chromatin/Epigenetic

2789580

C41H46N12O5S

818.95

C(C#N)C1(CN(S(CC)(=O)=O)C1)N2C=C(C=N2)C3=C4C(=NC(NC5=CC=C(C(NCCCN6CCN(CC6)C7=CC=C(C=C7)C8C(=O)NC(=O)CC8)=O)C=C5)=N3)NC=C4

-20°C

Ice Packs

PROTAC