SJ11646 - CAS 2933135-82-9

SJ11646 is a Dasatinib-based LCK PROTAC degrader with a DC50 of 0.00838 pM. It exhibits potent cytotoxicity against LCK-activated T-cell acute lymphoblastic leukemia (T-ALL) cells and primary leukemia samples, significantly prolongs LCK signal inhibition, and induces apoptosis in T-ALL cells. SJ11646 binds with high affinity to 51 human kinases, particularly ABL1, KIT, and DDR1. In mouse models of T-ALL, SJ11646 demonstrates exceptional anti-leukemic efficacy.

PROTACs, Apoptosis, Discoidin Domain Receptor (DDR), Src, Bcr-Abl

Cytoskeletal Signaling, PROTAC, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis

2933044

C36H40ClN9O5S

746.28

O=C(NC=1C(Cl)=CC=CC1C)C=2SC(=NC2)NC=3N=C(N=C(C3)N4CCN(CC4)CCCNC(=O)COC5=CC=C(C=C5)C6C(=O)NC(=O)CC6)C

-20°C

Ice Packs

PROTAC