SJ988497 - CAS 2595365-41-4

SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker, and the CRBN ligand Pomalidomide, SJ988497 is utilized in researching acute lymphoblastic leukemia (ALL) [1].

JAK, PROTACs

Angiogenesis, Stem Cells, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, PROTAC, JAK/STAT signaling

2595320

C36H36N10O5

688.74

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCNC(=O)C4=CC=C(NC5=NC(=C6C(=N5)NC=C6)C7=CN(CCC)N=C7)C=C4

-20°C

Ice Packs

PROTAC