SJF 1521 - CAS 2230821-40-4

SJF 1521 is an EGFR degrader belonging to the PROTAC class that selectively degrades EGFR while preserving HER2.

EGFR, PROTACs

JAK/STAT signaling, PROTAC, Angiogenesis, Tyrosine Kinase/Adaptors

2230777

0.992

C57H61ClFN7O9S

1074.65

N(C=1C2=C(C=CC(=C2)C3=CC=C(OCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@](C)(C)C)=O)C=C3)N=CN1)C7=CC(Cl)=C(OCC8=CC(F)=CC=C8)C=C7

-20°C

Ice Packs

PROTAC