SJF 8240 - CAS 2230821-68-6

C-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM) . Also degrades exon-14-deleted c-MET in Hs746T cells.

PROTACs, c-Met/HGFR, Others

PROTAC, Tyrosine Kinase/Adaptors, Others

2230747

C58H65F2N7O11S

1106.25

COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCOCCCOCCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |@:75|

-20°C

Ice Packs

PROTAC