SK2187 - CAS 3038446-91-9

SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.

PROTACs, Aurora Kinase

PROTAC, Chromatin/Epigenetic, Cell Cycle/Checkpoint

3038346

C45H49ClFN7O11S

950.43

C([C@@]1(C(NCCOCCOCCOCCNC(COC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)=O)CC[C@@H](OC5=C(F)C(Cl)=CC=C5)CC1)C=6N=C(NC7=NC=CS7)C=CC6

-20°C

Ice Packs

PROTAC