SK2188 - CAS 3038446-94-2

SK2188 is a potent and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM) . It induces DNA damage and apoptosis (Apoptosis), indirectly degrades MYCN, and inhibits tumor cell proliferation, offering insights for research on MYCN-amplified neuroblastoma.

Aurora Kinase, PROTACs, Apoptosis, Caspase

PROTAC, Apoptosis, Proteases/Proteasome, Cell Cycle/Checkpoint, Chromatin/Epigenetic

3038350

C43H46ClFN6O10S

893.38

C([C@@]1(C(NCCOCCOCCOCCOC2=C3C(C(=O)N(C3=O)C4C(=O)NC(=O)CC4)=CC=C2)=O)CC[C@@H](OC5=C(F)C(Cl)=CC=C5)CC1)C=6N=C(NC7=NC=CS7)C=CC6

-20°C

Ice Packs

PROTAC