SKF-96365 hydrochloride - CAS 130495-35-1

SKF-96365 hydrochloride (SKF96365), a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 hydrochloride treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ) /AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 hydrochloride inhibited hERG current in a concentration-dependent manner.

Potassium Channel, Apoptosis, Calcium Channel, Autophagy, TRP/TRPV Channel

Metabolism, Apoptosis, Membrane transporter/Ion channel, Autophagy

130459

0.9992

C22H27ClN2O3

402.91

Cl.COc1ccc(CCCOC(Cn2ccnc2)c2ccc(OC)cc2)cc1

-20°C

Ice Packs

Small Compound