SKF89976A HCl - CAS 85375-85-5

SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively) . SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM) . It is able to pass the blood-brain barrier after systemic administration and is active in vivo.

GABA Receptor, Others

Neuroscience, Others, Membrane transporter/Ion channel

85285

C22H25NO2

335.44

C(=CCCN1CC(C(O)=O)CCC1)(C2=CC=CC=C2)C3=CC=CC=C3

-20°C

Ice Packs

Small Compound