SKI2496 - CAS 1308378-95-1

SKI2496 is a potent and orally bioavailableantagonist of Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM; max. LH inh. inh. (%, h) = 84%, 12h; LH inh. (24h) = 76%.) . SKI2496 exhibits more selective antagonistic activity toward the human GnRH receptors over the GnRHRs in monkeys and rats.

ERK, Others, GNRH Receptor

GPCR/G Protein, Others, MAPK

1308282

C35H36F7N5O5

739.68

CC1=C(C(=O)N(C[C@H](NCCCC(O)=O)C2=CC=CC=C2)C(=O)N1CC3=C(C(F)(F)F)C=CC=C3F)N4CCN(CC=5OC(C(F)(F)F)=CC5)CC4

-20°C

Ice Packs

Small Compound