Molfinity

SKLB-197 - CAS 2713577-16-1

SKU:MF-0044939-01

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Product Details

Bioactivity
SKLB-197 is able to act on ATR (IC50: 0.013 μM), but has little or no activity on the other 402 protein kinases. In vitro and in vivo, SKLB-197 has shown significant antitumour effects against ATM-deficient tumours.
Target
Others, ATM/ATR
Related Pathways
Others, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair
CAS Number
2713560
Molecular Formula
C25H24N6O
Molecular Weight
424.5
SMILES
C[C@@H]1COCCN1c1nc(nc2ccc(cc12)-c1ccnn1C)-c1cccc2[nH]ccc12
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound