SKP-451 - CAS 181137-41-7

SKP-451 is an ATP-sensitive potassium (K+) channel agonist. It activates ATP-sensitive K+ channels, promoting the efflux of K+, leading to membrane hyperpolarization and inhibiting Ca2+ influx, which results in the relaxation of vascular smooth muscle. SKP-451 relaxes canine coronary arteries, rabbit basilar arteries, and vertebral arteries. Additionally, SKP-451 lowers mean arterial blood pressure in conscious spontaneously hypertensive rats (SHR) . It holds potential for cardiovascular disease research.

Potassium Channel

Membrane transporter/Ion channel

181089

C17H18N2O6

346.335

N(=O)(=O)C=1C=C2C(=C[C@](C)(OC2=CC1)[C@@H]3OCCO3)N4C(=O)CCC4

-20°C

Ice Packs

Small Compound