Skp2 inhibitor 2 - CAS 2760612-77-7

Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1. This compound targets Skp2, a component of cullin-RING ligases that recruits and ubiquitinates substrates, playing roles in both proteolytic and non-proteolytic processes [1].

E1/E2/E3 Enzyme

Ubiquitination

2760528

C27H32N4O

428.57

O=C(NCC1CCN(C2=NC(C3=CC=CC=C3)=C(N=C2)C=4C=CC=CC4)CC1)C(C)(C)C

-20°C

Ice Packs

Small Compound