SLC7A11-IN-2 - CAS 14668-59-8

SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.

Others, Reactive Oxygen Species

Immunology/Inflammation, Metabolism, Others, NF-κB

14601

C19H24N4O3

356.42

O=C(NNC=1C=CC=CC1)C(C(=O)NNC=2C=CC=CC2)CC(O)CC

-20°C

Ice Packs

Small Compound