SLMP53-2 - CAS 1826116-38-4

SLMP53-2 is a mutant p53 reactivator that restores the wild-type-like conformation and DNA-binding ability of mutp53-Y220C through enhanced interaction with Hsp70, thereby reinstating p53's transcriptional activity. This compound induces cell cycle arrest, apoptosis, and endoplasmic reticulum (ER) stress, displaying antitumor activity [1] [2].

Apoptosis, Others, MDM-2/p53

Apoptosis, Others

1826074

C26H22N2O2

394.47

C([C@@H]1N2[C@@](C=3C(C2=O)=CC=CC3)(OC1)C4=CC=CC=C4)C=5C=6C(N(C)C5)=CC=CC6

-20°C

Ice Packs

Small Compound