SLW131 - CAS 681511-84-2

SLW131 (Compound 10) is a CCR7 antagonist with strong affinity, showing a Ki of 9.85 nM. It inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM and β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 also suppresses CCL19-induced morphological changes in primary BMDC cells and CCR7-mediated migration of mouse CD4+ T cells.

CXCR

Immunology/Inflammation, GPCR/G Protein, Autophagy

681425

C21H27N5O5S

461.535

N([C@H]([C@@](C)(C)C)C=1OC(C)=CC1)C=2C(NC3=C(O)C(C(N(C)C)=O)=CC=C3)=NS(=O)(=O)N2

-20°C

Ice Packs

Small Compound