SM1044 - CAS 1331880-08-0

SM1044 is a dimer of dihydroartemisinin (DHA) . It activates caspase, inducing apoptosis in RL95-2 and KLE cells. SM1044 inhibits the proliferation of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, and AN3CA, with an IC50 of less than 3.6 μM. Additionally, SM1044 suppresses tumor growth in RL95-2 xenograft mouse models.

Apoptosis, Caspase

Apoptosis, Proteases/Proteasome

1331880-08-0

C34H55NO10

637.8

C[C@@H]1[C@]2([C@]34[C@](O[C@@H]1OCCNCCO[C@@H]5[C@H](C)[C@]6([C@]78[C@](O5)(O[C@](C)(OO7)CC[C@]8([C@H](C)CC6)[H])[H])[H])(O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])[H])[H]

-20°C

Ice Packs

Small Compound