SM875 - CAS 919023-94-2

SM875 is a degrader specifically targeting the cellular prion protein (PrP) with an IC50 of 7.87 μM. By binding to the folding intermediates of PrP, SM875 facilitates their degradation via the autophagy-lysosome pathway. It acts exclusively on nascent, immature PrP molecules and does not affect mature PrP synthesized beforehand. SM875 has the potential to inhibit prion replication, making it a promising compound for research in neurodegenerative diseases, particularly prion diseases.

Others

Others

918927

C19H16BrN3O3

414.25

O=C1NC2=C(C=NN2C3=CC=C(Br)C=C3)C(C4=CC=C(O)C(OC)=C4)C1

-20°C

Ice Packs

Small Compound