SMD-1087 - CAS 3033586-04-5

SMD-1087 is a selective PROTAC targeting SMARCA2 with a DC50 of 8 nM and a maximum degradation (Dmax) of 89%, while its DC50 for SMARCA4 exceeds 1 μM. The compound is composed of an E3 ligase ligand, (S, R, S) -AHPC-Me [blue part], a target protein ligand SMI-1074 [red part], and a PROTAC linker, (1r,4r) -tert-Butyl 4- (bromomethyl) cyclohexanecarboxylate [black part]. Notably, its target protein ligand plus linker section corresponds to the SMARCA2 Ligand-Linker Conjugate-1.

PROTACs, Others

PROTAC, Others

3033586-04-5

C56H68ClN7O5S

986.701

O=C1N=C2C3(C=4C(N2C=5C1=C(Cl)C=CC5)=CC(=CC4)C6CCN(C[C@H]7CC[C@H](C(N[C@H](C(=O)N8[C@H](C(N[C@@H](C)C9=CC=C(C=C9)C=%10SC=NC%10C)=O)C[C@@H](O)C8)C(C)(C)C)=O)CC7)CC6)CCCCC3

-20°C

Ice Packs

PROTAC