SMD-3040 - CAS 3033109-92-8

SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM), comprising an SMARCA2/4 ligand, a linker, and a VHL ligand. It exhibits excellent degradation selectivity for the SMARCA2 protein over the SMARCA4 protein and has demonstrated robust tumor growth inhibition in xenograft models [1].

PROTACs, Epigenetic Reader Domain

PROTAC, Chromatin/Epigenetic

3033009

C52H66N10O5S

943.21

CC1=C(C2=CC=C([C@@H](NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC([C@@H]4CC[C@@H](CN5CC6(CCC(N7C=C(C8=CC(C9=CC=CC=C9O)=NN=C8N)C=N7)CC6)C5)CC4)=O)C(C)(C)C)=O)=O)C)C=C2)SC=N1

-20°C

Ice Packs

PROTAC