SMI-10B13 - CAS 2502294-68-8

SMI-10B13 is an inhibitor of oncostatin M (OSM) with a dissociation constant (KD) of 6.6 μM. It effectively inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines, with IC50 values of 136 nM and 164 nM, respectively. SMI-10B13 demonstrates antitumor activity in a human breast cancer mouse model.

Interleukin, STAT

Immunology/Inflammation, Stem Cells, JAK/STAT signaling

2502218

C23H16N2O3

368.39

O=C(O)C=CC=1OC(C=2C=CC=3C=CNC3C2)=C(C1)C=4C=CC=5C=CNC5C4

-20°C

Ice Packs

Small Compound