SMTIN-T140 - CAS 2851532-40-4

SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 μM, exhibits anticancer activity by inducing mitochondrial dysfunction, elevating mitochondrial ROS production, and activating AMPK. Notably, SMTIN-T140 effectively suppressed tumor growth without discernible in vivo toxicity in a PC3 prostate cancer cell-xenografted mouse model [1].

AMPK, HSP, Reactive Oxygen Species

Metabolism, Cytoskeletal Signaling, NF-κB, Chromatin/Epigenetic, PI3K/Akt/mTOR signaling, Immunology/Inflammation

2851488

C36H34BrClFN5OP+

718.02

C1=CC=C(C=C1)[P+](CCCCCCN2C3=C(N=C(N=C3Cl)N)N(C2=O)CC4=C(C=C(C=C4)Br)F)(C5=CC=CC=C5)C6=CC=CC=C6

-20°C

Ice Packs

Small Compound