Smurf1-IN-1 - CAS 1824708-03-3

Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1].

E1/E2/E3 Enzyme

Ubiquitination

1824708-03-3

C24H29ClN6O2

468.98

O=C(C1=C(C)N(C2=CC=C(C3CC3)C=C2Cl)N=N1)NC4=C(C)N(C)N(C5CCCCC5)C4=O

-20°C

Ice Packs

Small Compound