Smurf1-IN-5 - CAS 1824647-09-7

Smurf1-IN-5 (Compound cpd-6) is an inhibitor of the SMAD ubiquitin regulatory factor (SMURF1) . It reduces the ubiquitination of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, thereby enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 holds promise for research in pulmonary arterial hypertension (PAH) .

E1/E2/E3 Enzyme

Ubiquitination

1824647-09-7

C25H22ClFN4O3

480.92

O=C(NC=1C(=O)N(C=2C=CC=CC2F)N(C1C)C)C3=NOC(C=4C=CC(=CC4Cl)C5CC5)=C3C

-20°C

Ice Packs

Small Compound