SN-38 - CAS 86639-52-3

SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM) . SN-38 has antitumor activity and induces autophagy.

ADC Cytotoxin, Autophagy, Drug Metabolite, DNA/RNA Synthesis, Topoisomerase

Autophagy, Metabolism, Antibody-drug Conjugate/ADC Related, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

86584

0.9997

C22H20N2O5

392.4

C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5

-20°C

Ice Packs

Small Compound