SN-398 - CAS 124623-00-3

SN-398, a derivative of Camptothecin, is an antitumor compound. It functions by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex to prevent DNA re-ligation, thereby inducing Topo I-mediated DNA breaks. In tests with Hela cells, SN-398 exhibits stronger antitumor activity than the original drug SN-38 (IC50=1.562 μM) . SN-398 is applicable for research on the antiproliferative and growth-inhibitory effects of Topo I in cancer cells.

Topoisomerase

DNA Damage/DNA Repair

124623-00-3

C22H19FN2O5

410.4

O=C1N2C(C=3C(C2)=C(CC)C=4C(N3)=CC(F)=C(O)C4)=CC5=C1COC(=O)[C@@]5(CC)O

-20°C

Ice Packs

Small Compound