SNIPER (ABL) -024 - CAS 2222355-77-1

SNIPER (ABL) -024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 5μM[1].

SNIPERs, Others, Bcr-Abl

Cytoskeletal Signaling, PROTAC, Tyrosine Kinase/Adaptors, Others, Angiogenesis

2222277

C52H61F3N8O9S

1031.15

C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCCNC(=O)C5=CC(=CC=C5)C=6C=C(NC7=CC=C(OC(F)(F)F)C=C7)N=CN6)=CC=C4)=CS3)[H]

-20°C

Ice Packs

PROTAC