SNIPER (ABL) -058 - CAS 2222354-61-0

SNIPER (ABL) -058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 10 μM[1].

SNIPERs, Others, Bcr-Abl

Angiogenesis, Tyrosine Kinase/Adaptors, Others, PROTAC, Cytoskeletal Signaling

2222293

C62H75N11O9S

1150.39

C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@@](CCC2)(C3=NC(C(=O)C4=CC(OCCOCCOCCOCC(=O)N5CCN(CC6=CC=C(C(NC7=CC(NC=8N=C(C=CN8)C=9C=CC=NC9)=C(C)C=C7)=O)C=C6)CC5)=CC=C4)=CS3)[H]

-20°C

Ice Packs

PROTAC