SNIPER (BRD) -1 - CAS 2095244-54-3

SNIPER (BRD) -1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+) -JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway and effectively degrades cIAP1, cIAP2, and XIAP with IC50 values of 6.8 nM, 17 nM, and 49nM, respectively[1].

SNIPERs, Epigenetic Reader Domain, Others

PROTAC, Chromatin/Epigenetic, Others

2095244-54-3

C53H66ClN9O8S2

1056.73

CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCCOC4=CC(C(=O)C=5N=C(SC5)[C@]6(N(C([C@@H](NC([C@@H](NC)C)=O)C7CCCCC7)=O)CCC6)[H])=CC=C4)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C

-20°C

Ice Packs

PROTAC