Sodium dichloroacetate - CAS 2156-56-1

Sodium dichloroacetate (BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

PDK, ROS, Reactive Oxygen Species, Apoptosis, Dehydrogenase, Na-K-Cl cotransporter

Membrane transporter/Ion channel, Metabolism, PI3K/Akt/mTOR signaling, NF-κB, Apoptosis, Immunology/Inflammation

2099

0.9987

C2HCl2NaO2

150.92

C(C(=O)[O-])(Cl)Cl.[Na+]

-20°C

Ice Packs

Natural Product