SOR-C13 - CAS 1187852-48-7

SOR-C13 is an inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in tumor cells overexpressing TRPV6.

TRP/TRPV Channel

Membrane transporter/Ion channel

1187797

C72H116N20O19

1565.81

C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCCCN)N)=O)CCC(O)=O)=O)=O)CC(C)C)=O)(=O)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CCC4)CC(C)C)=O)CC(O)=O)=O)[C@H](C)C)=O)CCCCN)=O)CO)=O)CCC3

-20°C

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Peptide