Sorafenib - CAS 284461-73-0

Sorafenib (Bay 43-9006) is a multikinase inhibitor that targets Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/58 nM) with oral activity. It exhibits antitumor properties and can induce autophagy, apoptosis, and agonistic iron death.

PDGFR, c-Kit, Autophagy, Raf, Apoptosis, VEGFR, Ferroptosis, FLT

Angiogenesis, Autophagy, MAPK, Tyrosine Kinase/Adaptors, Apoptosis

284461-73-0

0.9989

C21H16ClF3N4O3

464.82

O(C=1C=C(C(NC)=O)N=CC1)C2=CC=C(NC(NC3=CC(C(F)(F)F)=C(Cl)C=C3)=O)C=C2

-20°C

Ice Packs

Small Compound