Sotiburafusp alfa - CAS 2637466-37-4

Sotiburafusp alfa is a humanized bispecific fusion protein comprising a VEGFR-1 extracellular domain fragment (129-228, 1-100 in the current sequence) connected through a 101 GGSGGSGGSGGSGGS 115 peptide linker to the N-terminus (116-564) of a humanized IgG1-kappa anti-human PD-L1 heavy chain with L352>A and L353>A mutations. Additionally, sotiburafusp alfa functions as an angiogenesis inhibitor [1].

PD-1/PD-L1, VEGFR

Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Angiogenesis, Immunology/Inflammation, Apoptosis

2637466-37-4

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Peptide