Sotorasib - CAS 2296729-00-3

Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.

Kras, Ras

MAPK, GPCR/G Protein

2296729-00-3

0.9995

C30H30F2N6O3

560.594

O=C1N=C(C=2C=C(F)C(=NC2N1C=3C(=NC=CC3C)C(C)C)C=4C(F)=CC=CC4O)N5CCN(C(=O)C=C)CC5C

-20°C

Ice Packs

Small Compound