Sotuletinib dihydrochloride - CAS 2222138-40-9

Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable CSF1-R inhibitor with an IC50 of 1 nM, promoting apoptosis in tumor cells and significantly restricting tumor growth in murine models, thereby proving useful in cancer and amyotrophic lateral sclerosis (ALS) studies [1].

C-Fms

Tyrosine Kinase/Adaptors

2222089

C20H24Cl2N4O3S

471.4

N(C=1SC=2C(N1)=CC=C(OC=3C=C(C(NC)=O)N=CC3)C2)[C@H]4[C@H](O)CCCC4.Cl.Cl

-20°C

Ice Packs

Small Compound