Sotuletinib hydrochloride - CAS 2222138-31-8

Sotuletinib hydrochloride (BLZ945 HCl) is a selective, brain-penetrant CSF-1R (c-Fms) inhibitor (IC50=1 nM), exhibiting 1000-fold greater selectivity than other receptor tyrosine kinase homologues. It elevates liver enzymes and induces Kupffer cell depletion, making it suitable for studying amyotrophic lateral sclerosis (ALS) and metastatic triple-negative breast cancer (TNBC) .

C-Fms, CSF-1R

Tyrosine Kinase/Adaptors

2222099

0.98812

C20H23ClN4O3S

434.94

N(C=1SC=2C(N1)=CC=C(OC=3C=C(C(NC)=O)N=CC3)C2)[C@H]4[C@H](O)CCCC4.Cl

-20°C

Ice Packs

Small Compound