Sp-2-Cl-cAMPS - CAS 124854-63-3

Sp-2-Cl-cAMPS serves as an agonist for PKA, boasting enhanced membrane permeability and stability against phosphodiesterases. This compound exhibits antimalarial activity, inhibiting the proliferation of the malaria parasite Plasmodium falciparum with an EC50 of 4 μM. Furthermore, Sp-2-Cl-cAMPS binds to the purified regulatory subunit of PfPKA (PfPKAr) with a Ki of 1.3 μM.

Parasite, PKA

Tyrosine Kinase/Adaptors, Microbiology/Virology

124854-63-3

C10H11ClN5O5PS

379.72

NC1=C2C(N(C=N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(S)O4)[H])[H])=NC(Cl)=N1

-20°C

Ice Packs

Small Compound