SPA0355 - CAS 1251839-15-2

SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand) -induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.

NF-κB, Akt, p38 MAPK, RANKL/RANK

MAPK, NF-κB, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

1251822

C22H21N3O2S

391.486

S=C(NC1=CC=C(OCCN2C=3C=CC=CC3OC=4C=CC=CC42)C=C1)NC

-20°C

Ice Packs

Small Compound