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SPA107 - CAS 179939-69-6

SPA107 - CAS 179939-69-6

MF-0112450-01

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Product Details

  • Bioactivity

    SPA107 (Hemiasterlin methyl ester) is an analogue of Hemiasterlin. It inhibits tubulin polymerization, exhibiting antimitotic activity with an IC50 of 0.5 nM. SPA107 also shows cytotoxicity against p53 mutated MCF-7 cells, with an IC50 of 0.5 nM.

  • Target

    Others, Microtubule Associated

  • Related Pathways

    Others, Cytoskeletal Signaling

  • CAS Number

    179864

  • Molecular Formula

    C31H48N4O4

  • Molecular Weight

    540.74

  • SMILES

    C([C@@H](C(N[C@H](C(N([C@H](/C=C(/C(OC)=O)\C)C(C)C)C)=O)[C@](C)(C)C)=O)NC)(C)(C)C=1C=2C(N(C)C1)=CC=CC2

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound