SPI-001 - CAS 1220996-46-2

SPI-001 is a selective inhibitor of PPM1D (IC50=0.48 μM) that exhibits anticancer activity. The compound inhibits the phosphatase activity of PPM1D in human breast cancer cells overexpressing PPM1D and enhances the phosphorylation of p53. Additionally, SPI-001 suppresses cell proliferation by inducing apoptosis.

Phosphatase, Apoptosis, MDM-2/p53

Metabolism, Apoptosis

1220996-46-2

C30H60O4Si2

540.97

C[C@@]12[C@]([C@@H](O[Si](C(C)(C)C)(C)C)C[C@]3([C@]1(C[C@@H](C)C[C@H]3O[Si](CC)(CC)CC)[H])[H])([C@@](CO)(C)C[C@H](O)C2)[H]

-20°C

Ice Packs

Small Compound