SpiD3 - CAS 3033533-25-1

SpiD3 is an antitumor spirocyclic dimer with the advantage of being independent of TME (tumor microenvironment) stimulation. It induces apoptosis in chronic lymphocytic leukemia (CLL) cells, inhibits NF-κB activation, upregulates the UPR (unfolded protein response), and suppresses protein synthesis. It can be used to study BTK-mutated CLL.

NF-κB, Apoptosis

Apoptosis, NF-κB

3033533-25-1

0.9915

C27H22N2O6

470.47

O=C1OC2(C(=O)N(C=3C=CC=CC32)CCCN4C(=O)C5(OC(=O)C(=C)C5)C=6C=CC=CC64)CC1=C

-20°C

Ice Packs

Small Compound