SR-0813 - CAS 2597186-19-9

SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9, with an IC50 of 25 nM and EC50 of 205 nM for the ENL YEATS domain, and an IC50 of 311 nM and EC50 of 76 nM (CETSA) for the AF9 YEATS domain. It shows over 100-fold lower affinity for MAP3K19 (Kd = 3.5 μM) compared to ENL YEATS (Kd = 30 nM) . SR-0813 can be utilized in acute leukemia research.

Epigenetic Reader Domain

Chromatin/Epigenetic

2597158

0.9972

C25H32N6O3S

496.62

C(NC1CCC1)(=O)C2=CN3C(=NC(=C3)C4=CC(NS(NCCN5CCCCC5)(=O)=O)=CC=C4)C=C2

-20°C

Ice Packs

Small Compound