SR12418 - CAS 1801185-08-9

SR12418 is a specific synthetic ligand for REV-ERB, demonstrating binding affinity for both REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. SR12418 inhibits IL-17A expression in EL4 cells and suppresses TH17 cell differentiation, making it suitable for studies on experimental autoimmune encephalomyelitis (EAE) and colitis.

Autophagy, REV-ERB, IL Receptor

Immunology/Inflammation, Autophagy, Metabolism

1801185-08-9

0.9996

C31H30FNO3

483.57

C(=O)(N1[C@H](COC2=CC=C(OC(C)(C)C)C=C2)CC=3C(C1)=CC=C(F)C3)C=4C5=C(C=CC4)C=CC=C5

-20°C

Ice Packs

Small Compound