SRI-31142 - CAS 1940118-04-6

SRI-31142 is a proposed brain-penetrant allosteric inhibitor of the dopamine transporter (DAT) . In behavioral studies utilizing intracranial self-stimulation (ICSS), SRI-31142 does not produce the abuse-related effects observed with cocaine and GBR-12935. Instead, at effective doses, it reduces ICSS responding and dopamine levels in the nucleus accumbens (NAc) . Additionally, SRI-31142 can prevent cocaine-induced increases in ICSS and NAc dopamine.

Dopamine Receptor

Neuroscience, GPCR/G Protein

1940118-04-6

C29H24N6

456.54

N=1C=CC(=CC1)C(C=2C=CC=CC2)CNC3=NC(=NC=4C=CC=CC43)C5=CN6C=CN=C6C=C5C

-20°C

Ice Packs

Small Compound