SRI-31255 - CAS 905580-86-1

SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.

LRRK2

Autophagy

905493

C15H14N4

250.3

N([C@@H]1C=2C(CC1)=CC=CC2)C3=C4C(NC=C4)=NC=N3

-20°C

Ice Packs

Small Compound