SRI-41315 - CAS 1613509-49-1

SRI-41315 is an eRF1 degrader that acts as a molecular glue at the center of ribosomal decoding.SRI-41315 induces an extended pause at the termination codon and inhibits cystic fibrosis-associated PTC in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function.SRI-41315 inhibits PTC by decreasing the abundance of the termination factor eRF1 NIOCH 14

CFTR

Membrane transporter/Ion channel

1613459

0.9987

C22H19N3O2

357.41

O=C1C=2C=CC=CC2N(C=3N=C(N(C=4C=CC=CC4)C(=O)C13)C5CCC5)C

-20°C

Ice Packs

Small Compound